Fifth Ave is doable, but trafficy. There are times when I'll do the sidewalk on fifth - but there are plenty of pedestrians too, so that is sometimes either really slow, somewhat inconsiderate of me, or sometimes both.
A calmer route is (assuming you are east of Aiken) north to Howe street, dogleg right and left to Westmister or Pembroke. Then one block is the wrong way on a one way street (if you are fastious about traffic laws, you could get off and walk, it's a short block), after that block the road is two way. From Westmister, right on Amberson and left on Castleman (from Pembroke is L then R).
Left on Morewood, Right through the Synagog parkihng lot. Left of Devonshire and right through the church parking lot. From there, I take fifth in.
Coming back the pattern of one-way streets is different, but they usually aren't a problem.
Riding this is a lot less complicated than it sounds after you've done it once.
If you are going to the buildings along Ohara Street (Chem, physics, engineering, Western Psych, the med school, Petersen sports center) it makes sense to go north to Ellsworth, right on Devonshire, and left on Bayard (which becomes Bigelow, which becomes O'hara)
Good luck.