You should have no trouble following it. It is really well marked the entire way. The only problems I have had are following it through Lancaster. There are signs I believe it is 200 feet before any turn, then a sign at the turn pointing you in the right direction, and then a confirmation sign 100 - 200 feet after you make a turn.
The Route S maps you can get on the state's web site (i forgot the URL because I have the PDF on my computer) are very good.