I completely agree with dmtroyer about Smallman. It's pretty clear that the bike route designation wasn't made by someone who actually commutes there. I think it was made by looking at numbers in a spreadsheet.
I'm happy riding Penn inbound from Butler onward, but the hill down from 40th St is always a bit scary. It's too narrow to share safely with autos, so you have to take the lane. Once having taken the lane, you naturally want to ride at 30-40 mph to justify being there and discourage stupid passing. But the road surface is crappy and there are always people trying to edge out from the side streets who can't see out around the parked cars. By the time they can see me, there's definitely no time for them to pull out, but I'm always afraid that someone is going to misjudge my speed and do it anyway, but too late for me to react in time (particularly given the crappy surface -- you just can't brake effectively over bumpy pavement). So I'm always muttering "don't you do that, don't you dare pull out". The hill down Liberty is wide open and has better surface, so I'm happier with that. Well, I was happier still before the downhill bike lane was striped. The uphill one is fine for fat slow me in my lowest gear but the downhill one is too narrow and too close to the cars for riding at the kind of speeds that you reach just by coasting. But I feel pressured to be in it even though I know it's unsafe. Which means I am probably now riding farther right than I ought to. I haven't been honked and hollered at there yet, but I also moved out of that neighborhood so I am more likely to take 5th inbound instead of either Liberty or Penn.
You really should avoid the Liberty bike lane if you're doing 35-40 mph -- it's too close to the cars for that speed, on account of (a) doors (b) visual clutter and visibility to crossing traffic (c) making yourself "matter" to that oncoming left-hook bus.
I rode Liberty inbound pretty frequently -- about a hundred times a year, I guess -- for a couple of different years out of the last 5, and I only once had a scary moment, when someone in a van just had to pass me and then turn right in front of me. I didn't have to do anything heroic, just slam on the brakes, but it was a little frightening and maddening for having been so damn pointless. I never got left-crossed by a bus, so maybe that's coincidence, or maybe there is something to be said for different lane positioning.
Bike type, tires, and speed are going to make a lot of difference in where you ride. Some roads that are difficult to ride with a road bike are no trouble with a hybrid, and vice versa. Also, as you learn more about how to be seen by and communicate with the motorists, you will discover that your road preferences will change.